ABSTRACT OF PROJECT
has incorporated the ADHA Xerostomia with Hyposalivation Tool under risk assessment.
Fast Docs Index
ADHA XEROSTOMIA WITH HYPOSALIVATION
SCREENING TOOL PROJECT
Background and Significance of Project
The goal of the ADHA Hyposalivation with Xerostomia Screening Tool Project is to develop a validated screening tool for use in dental practices as an aid to provide greater awareness and accuracy in the screening, assessment, and management of hyposalivation with xerostomia. 1 Funded initially for its creation by an Unrestricted Educational Grant provided by GSK, the tool utilizes ADHA Standards for Clinical Dental Hygiene Practice regarding the assessment, etiology, and management of conditions related to hyposalivation with xerostomia. The tool was presented to the ADHA members via an article in their Access magazine (see Document), which contains further background and specific aims of the screening tool as well as how to use the tool in an office setting. 2 Seminars related to the use of the tool were also offered and given to ADHA members. An Internet video (YouTube) was also created to inform ADHA membership and then updated. The tool and the related Project was also presented to members at an ADHA Annual Session at a CLL Poster Session as noted in the Journal of Dental Hygiene (page 381) as well as at the International Association of Dental Research, Seattle, WA (2013).
Preliminary Review of Screening Tool
At this time, the tool has been reviewed by a dental hygienist working in a high-risk practice for hyposalivation (head and neck cancer patients), Linda Choquette, RDH, MSHS, CCRP. She felt after trying it on high-risk patients that it met her needs to importantly discern between moderate and high-risk patients and could be accomplished in under 3 minutes with familiarity without use of the computer for tallying; however, she feels it could be much faster using a computerized tool.
The tool has also been reviewed by one noted expert in the field, Philip C. Fox, DDS, FDS, RCSEd, who is the author of the ADHA continuing education course on xerostomia. 3 He was a visiting scientist at the Department of Oral Medicine, Carolinas Medical Center, Charlotte, NC, and is an independent biomedical consultant focusing primarily in the area of clinical trial design and analysis. He is also a diplomate of the American Board of Oral Medicine, as well as establishing the first Sjögren’s Syndrome Clinic, with the Molecular Physiology and Therapeutics Branch, NIDCR, Bethesda, MD. Dr. Fox felt overall that it met the needs of the dental community but its validation would serve to confirm this.
Poster for Project (click to viewable full size PDF)
Proposed Methods and Measurements for Validation
The next step is to clinically validate this screening tool for hyposalivation so the intended audience of dental professionals can know that it is evidence-based in its approach when working with dental patients in dental practice. This could be accomplished by the following suggested methods and measurements using any necessary administrative, clinical, and laboratory resources.
As to the methods, initially, one hundred participants in a selected clinical setting with the primary symptom of xerostomia would be used in the study and assigned another study appointment after signing up to participate. 4, 5, 6 The participants in the study would not have an intellectual disability or English as a second language or be pregnant or under 18 years of age. Participants would be instructed not to drink, eat, smoke, perform oral hygiene or put anything into their mouths for 90 minutes before this next appointment since saliva samples will be collected in order to measure the participant’s salivary flow (sialometry). The appointment confirmation courtesy call would review these instructions.
Each participant would first be evaluated using the developed Screening Tool by a dental hygienist to determine the participant’s risk level for hyposalivation, not as part of any routine dental visit, but as a separate appointment. The dental hygienist has the necessary background in anatomy, pharmacology, and physiology to complete task, and if in a dental practice setting, would have the necessary practice contact.
One effective way to obtain objective measurements of quantitative changes in saliva is by collecting saliva. Collecting whole saliva is easier and more cost-effective than collecting saliva from an individual gland (parotid, submandibular, or sublingual). Whole saliva would be collected under both unstimulated (resting) and stimulated conditions. After the evaluation, the saliva would be collected in a quiet environment, with the participant sitting in an upright position, head tilted forward and eyes open, with minimal body and orofacial movements. 7, 8
To collect the unstimulated saliva, the participant is asked to swallow any saliva in their oral cavity first, then stay motionless and allow the saliva to drain passively for five minutes over the lower lip into a preweighed 15 ml test tube fitted with a 55 mm diameter funnel, avoiding any further swallowing. After the five-minute collection period, the participant is asked then to void the mouth of saliva by spitting into the funnel. 9, 10
After unstimulated saliva is collected, the stimulated saliva is then collected after asking the participant to chew on a piece of paraffin wax at approximately 45 chews per minute. Wax is used for cost effectiveness and also reduces any individual participant concerns as to taste or texture or content associated with using gum or candy. The participant will void the mouth of saliva by spitting into another similar collection tube every minute for a total of five minutes.
Both collection tubes will be weighed chairside after each collection using a small scale with the numbers entered using the Saliva Collection Form. Later the participant’s salivary flow rate for both the unstimulated and stimulated flow is calculated by dividing the amount (weight) of collected saliva by the duration of the collection period (five minutes).
The responses to the tool and salivary flow rates for each participant would undergo data analysis in comparison to known values to determine the validity of the Screening Tool to adequately evaluate the risk level for hyposalivation. Later this information would be presented to the dental community in various publications.
While there is no general agreement about what constitutes a “normal” salivary flow rate; researchers generally consider an unstimulated flow rate of 0.1 to 0.2 milliliters per minute (or grams per minute) and a chewing stimulated flow rate of 0.7 mL/minute (or g/minute) to be abnormally low flow rates. Currently, clinicians use a 0.1-mL/minute unstimulated whole saliva flow rate as a criterion for the diagnosis of Sjögren’s syndrome. A chart was devised using these values for comparison of normal and abnormal whole saliva flow rates in both unstimulated and stimulated whole saliva (see Table 1). 11
Table 1: Comparison of normal and low whole saliva flow rates in both unstimulated and stimulated saliva rates.
Author of Project
The Author is a Dental Hygiene Education Consultant, Oral Biologist, and Dental Science Technical Writer. She has obtained her Certificate in Clinical Research from the UW School of Dentistry. She is the recent recipient of both the ADHA A.C. Fones (2013) and Award of Excellence (2009). She can be reached at LinkedIn
Updated References for Project
1. ADHA: Standards of Clinical Dental Hygiene Practice (2016) at http://www.adha.org/resources-docs/2016-Revised-Standards-for-Clinical-Dental-Hygiene-Practice.pdf
2. Fehrenbach, MJ: American Dental Hygienists’ Association hyposalivation with xerostomia screening tool, Access, ADHA, Dec. 2012 at www.dhed.net/ADHA_Access_Hyposalivation_Tool.pdf
3. Fox PC. Xerostomia: Recognition and Management, Access Supplementary Issue, Feb. 2008 at adha.cdeworld.com/courses/2008; must register
4. Tanasiewicz M, Xerostomia of Various Etiologies: A Review of the Literature. Adv Clin Exp Med. 2016 Jan-Feb;25(1):199-206.
5. Plemons JM, Managing xerostomia and salivary hypofunction: executive summary of a report from the American Dental Association Council on Scientific Affairs. J Am Dent Assoc. 2014 Aug;145(8):867-73.
6. Riley P, Pharmacological interventions for preventing dry mouth and salivary gland dysfunction following radiotherapy. Cochrane Database Syst Rev. 2017 Jul 31;7:CD012744.
7. Fehrenbach, MJ, Popowics T. Illustrated dental embryology, histology, and anatomy. Ed 5. Saunders, Philadelphia, PA, 2021
8. Fehrenbach MJ, Herring SW. Illustrated anatomy of the head and neck. Ed 6. Saunders, Philadelphia, PA, 2020
9. Navazesh M, et al. Measuring salivary flow: Challenges and opportunities. JADA 2008;139 Suppl:35S-40S
10. Johansson AK, et al; A comparison of two clinical methods for measuring saliva in patients with Sjögren's syndrome. Acta Odontol Scand. 2012;70(3):251-4
11. Ship J, Fox PC, Baum BJ. How much saliva is enough? ‘Normal’ function defined. JADA 1991;122:63-9
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